Endocrine Abstracts

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on pain reduction and on improving the quality of life of the patient. Particularly patients with multiple metastatic lesions benefit from bone-targeting therapeutic radiopharmaceuticals....

Objectives: DOTAMZOL is a DOTA-conjugated bisphosphonate which can be used for diagnostic (44Sc, 68Ga) or therapeutic (177Lu) applications. The aim of this study was to evaluate the adaption of the radiolabelling process on an automated module utilizing NaCl-post processing, with regard to clinical application and additional radiation protection point of view.Methods: 68Ga was obtained from a 1.5 yea...